Colts declared CB Sauce Gardner, LB Jaylon Charlies, RB DJ Giddens, WR Anthony Gould, S Reuben Lowery III, TE Will Mallory, and T Bernhard Raimann inactive for Week 16 against the 49ers.
Gardner’s absence is likely the most detrimental after the Colts shifted away from a Cover-3-heavy structure in favor of increased rates of man coverage after acquiring the standout cornerback at the trade deadline. Expect the team to turn back to a Cover-3 base in his stead in what amounts to a must-win game for the Colts.