Patrick Mahomes threw 159 passes this season, 14 of them touchdowns, before throwing his first interception of the season.
Safety Tashaun Gipson intercepted a pass intended for Tyreek Hill down the field in the second quarter.
But Jacksonville gave the ball right back when Dee Ford had a strip-sack of Blake Bortles that Breeland Speaks recovered at the Kansas City 49.
The Chiefs have rolled to 216 yards against the league’s top-ranked defense with two minutes remaining in the first half. They lead 13-0.
