The Buccaneers trailed only 13-7 at halftime. They trail 27-7 after three quarters.
The 49ers opened the second half with a three-play, 98-yard drive and a nine-play, 79-yard drive. San Francisco now has 378 yards.
Brock Purdy has completed 19 of 22 passes for 315 yards and three touchdowns, a perfect passer rating of 158.3. His touchdown throws were 4 yards to Christian McCaffrey, 76 yards to Brandon Aiyuk and 3 yards to George Kittle.
Kittle now has seven receptions for 77 yards.
The Buccaneers have 168 yards and without a big fourth-quarter comeback are on their way to 4-6 on the season.
The bad news for the 49ers is the loss of safety Talanoa Hufanga, who was carted off with a knee injury. The 49ers have ruled him out. Rookie Ji’Ayir Brown has replaced him.
The Bucs have ruled out linebacker Lavonte David with a groin injury.
