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The 95 yards were easily a new season high thanks to a 60-yard catch-and-run in the third quarter. McCloud also posted five receptions for the second game in a row after previously going five contests without doing so. Good for McCloud, but not really fantasy relevant with Kirk Cousins’ struggles deepening heading into Week 14 against the Vikings.

10 players registered counting stats in the box score under receiving, with Knox amassing the most yardage of the bunch. Even quarterback Josh Allen got in on the receiving fun, taking a lateral from wide receiver Amari Cooper to the house from seven yards out. Either way, Knox is unlikely to return usable counting stats consistently even with Dalton Kincaid still nursing a knee issue.

Davis saw additional usage with the Bills in complete control in blizzard-like conditions, with a 65-yard touchdown scamper from starter James Cook aiding in that endeavor. Davis is unlikely to see bankable weekly volume but carries solid per-touch upside in one of the league’s top offenses.

The highlight of Cook’s evening came on a 65-yard touchdown run down the right sideline in the second quarter, which paved the way for Ray Davis to notch 11 carries of his own. Cook needed only 14 carries to surpass 100 yards on the ground after his long touchdown run, something that fantasy managers have grown to understand of Cook in Buffalo in that he is never really counted on for massive volume but always carries game-breaking upside. Cook’s next chance to return a viable fantasy week comes against the Rams in Week 14.

Allen became the first quarterback in NFL history to throw a touchdown, rush for a touchdown, and catch a touchdown in the convincing win. The receiving touchdowns goes down without a reception after Allen completed a pass to Amari Cooper, who lateraled the football back to Allen after being held up at the seven. Allen did the rest as he dove to the front pylon. He would then achieve history in the fourth quarter, hitting the trifecta on an eight-yard touchdown plunge in driving snow. All and the Bills have rattled off seven consecutive wins to remain one game back of the Conference-leading Chiefs.

It was a game to be forgotten by the 49ers in what became swirling blizzard-like conditions due to lake effect in Buffalo. Furthering the dismay for the 49ers was the departure of running back Christian McCaffrey five minutes into the second quarter, who appears likely to miss the remainder of the season with a PCL injury. That could bring back the consistency to Kittle’s game the rest of the way, with his next opportunity to return a usable fantasy score coming in Week 14 against the Bears.

Samuel struggled mightily with the rest of the team in the face of blizzard-like conditions in Buffalo. The 49ers managed just 239 total yards of offense while largely struggling to move the ball, due in part to the weather and due in part to being seemingly overmatched in every area of the field. Samuel’s next chance to return a usable fantasy score will come in Week 14 against the reeling Bears.

The hits just keep coming for the 49ers, who not only fell to 5-7 and two games behind the division-leading Seahawks but they now potentially lost their All-Pro running back (again). McCaffrey gave himself up behind the offensive line on a carry five minutes into the second quarter. He was able to walk under his own power to the medical tent and then the locker room, but initial testing revealed a potentially season-ending PCL injury. While the severity is not yet known, it is horrible news for the alpha running back that managed just three fully healthy games this season. Further testing Monday will reveal more.

Jennings led the team in targets and yardage on a night the two teams were contending with blizzard-like conditions, something that held quarterback Brock Purdy to just 18 pass attempts. Jennings continues to produce with the increased opportunity following the season-ending injury to Brandon Aiyuk and could be tasked with more with the 49ers suddenly two games back for the division lead and expecting to be without running back Christian McCaffrey for the remainder of the season.

Similar to early in the season without Christian McCaffrey, Mason ran well but lacked the same pass game involvement of a healthy CMC, rushing to 6.0 yards per carry but failing to garner a single target. McCaffrey departed the game five minutes into the second quarter with what the team is calling a knee injury after giving himself up behind the offensive line. He was able to walk under his own power to the medical tent and then to the locker room but did not return, meaning we could be getting another Mason start in Week 14 when the 49ers take on the reeling Bears.

Purdy and the San Francisco offense struggled to move the football throughout but were dealt a crushing blow five minutes into the second quarter when All-Pro running back Christian McCaffrey departed with a knee injury after giving himself up behind the line of scrimmage. The modest 18 pass attempts from Purdy highlighted both the tricky weather conditions and a general inability to move the football against the aggressive Buffalo defense. The 49ers fell to 5-7 and are now two games behind the Seahawks for the division lead with only five games left to play. Up next for the 49ers is a similarly downtrodden Bears team in Week 14, a game they might now have to play without McCaffrey.