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Titans vs. Browns prediction: Odds, expert picks, QB matchup, injury update, betting trends, and stats

Sunday in Cleveland, the Browns (3-9) host the Tennessee Titans (1-11) in a battle for draft position between two of the worst teams in the NFL.

The Titans loan win this season was two months ago on October 5th against Arizona. They have been dreadful, especially on offense although they do believe in last year’s top overall draft pick, Cam Ward. Currently sitting atop the Draft again this year, Tennessee is no doubt hoping QB-needy teams will ultimately overpay for the likes of a Fernando Mendoza or a Dante Moore. A loss in Cleveland puts them closer to finishing back-to-back seasons with the worst record in the NFL.

The Browns sure look like one of those teams who will be looking...yet again...for their franchise quarterback in the offseason. Rookies Dillon Gabriel and Shedeur Sanders have failed to show enough to make Browns’ management believe in either.

The difference between these teams is the Browns’ elite defense. Myles Garrett and co. is this team’s only path to victory each week. Its a safe bet they will do enough to stymie the Ward and the Titans. But can the offense do their part? That’s why tot Total is so embarrassingly low.

Tickets for this one are selling for as little as $3 but that does not mean we won’t find an angle or two to bet. Lets take a deeper dive into this week’s matchup between the Titans and the Browns.

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates courtesy of Rotoworld, and of course our predictions and best bets for the game from our staff of experts.

Game Details and How to watch the Titans vs. Browns live Sunday

  • Date: Sunday, December 7, 2025
  • Time: 1:00PM EST
  • Site: Huntington Bank Field
  • City: Cleveland, OH
  • Network/Streaming: FOX

Want to check out the other games on the NFL schedule this week? We’ve got you covered at NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Game odds for the Titans at the Browns

The latest odds as of Wednesday courtesy of DraftKings:

  • Moneyline: Tennessee Titans (+170), Cleveland Browns (-205)
  • Spread: Browns -3.5
  • Total: 33.5 points

This game opened at Browns -4.0 with the Game Total set at 33.5.

Be sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the NFL schedule!

Editor’s Note: DraftKings Sportsbook is now live in Missouri! New customers, download the app and sign up to claim your exclusive offer!

Quarterback Matchup for Tennessee at Cleveland

  • Titans Starting QB: Cam Ward
    Last Game: 11/30 vs. Jacksonville - 24-38, 141yds, 0TDs, 0INTs, Sacked 3 times, 1 carry for 7yds rushing
    Season: 12GP, 246-412, 2351yds, 7TDs, 6INTs, Sacked 48 times, 28 carries for 123yds rushing
  • Browns Starting QB: Shedeur Sanders
    Last Game: 11/30 vs. San Francisco - 16-25, 149yds, 1TD, 0INTs, Sacked 3 times, 1 carry for 6yds rushing
    Season: 3GP, 31-61, 405yds, 2TDs, 2INTs, Sacked 6 times, 5 carries for 21yds rushing

Titans at Browns team stats, betting trends

  • Myles Garrett leads the NFL with 19.0 sacks this season
  • Garrett needs 4 sacks to set the NFL single-season sack record (2001 Michael Strahan, 2021 T.J. Watt – both with 22.5)
  • Cam Ward has taken an NFL-high 48 sacks this season, exactly 4.0 sacks/game
  • Garrett has 3 games with 3+ sacks this season, 1 shy of tying Lawrence Taylor (1986) for the most games in a season all-time
  • The Browns have won 4 of their last 5 games against the AFC South
  • Each of these teams is 5-7 ATS this season
  • The Browns are 7-3 ATS in their last 10 games as a home favorite (that stat goes back more than a couple years)
  • The OVER is 4-1 in the Browns’ last 5 games against AFC teams
  • The OVER has cashed in 6 of the Browns’ 12 games this season (6-6)
  • The OVER has cashed in 7 of the Titans’ 12 games this season (7-5)
Garrett, Harris call out Jennings
Mike Florio and Devin McCourty react to Shelby Harris and Myles Garretts' comments on Jauan Jennings, discussing why the 49ers receiver has found himself in the middle of multiple skirmishes.

Titans Player Injuries

  • C Lloyd Cushenberry III (foot) is listed as questionable for Sunday’s game
  • S Amani Hooker (ribs) is listed as questionable for Sunday’s game
  • S Kendell Brooks (concussion) is listed as questionable for Sunday’s game
  • DT Shy Tuttle (concussion) is listed as questionable for Sunday’s game
  • CB Jalyn Armour-Davis (Achilles) is listed as questionable for Sunday’s game

Browns Player Injuries

  • QB Deshaun Watson (Achilles) has been designated to return to practice but has not been activated
  • DE Adin Huntington (quad) is listed as questionable for Sunday’s game
  • DE Alex Wright (quad) is listed as questionable for Sunday’s game
  • TE Brenden Bates (ankle) is listed as questionable for Sunday’s game
  • DT Maliek Collins (quad) has been placed on IR and is OUT for Sunday’s game
  • RT Jack Conklin (concussion) is listed as questionable for Sunday’s game
  • RG Wyatt Teller (calf) is listed as doubtful for Sunday’s game
  • RB Dylan Sampson (calf) is listed as questionable for Sunday’s game

Rotoworld Best Bets

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, stadium information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Best bets our model is projecting for this week’s game between the Titans and the Browns

  • Moneyline: Rotoworld Bet is staying away from a play on the Moneyline.
  • Spread: Rotoworld Bet is leaning towards a play ATS on the Cleveland Browns at -3.5.
  • Total: Rotoworld Bet is recommending a play on the OVER on the Game Total of 33.0.

Rotoworld has you covered with all the latest betting info & tools for NFL with player news, game predictions, player props, futures, and trends!

Follow our experts on socials to keep up with all the latest content from the staff:

● Jay Croucher (@croucherJD)
● Drew Dinsick (@whale_capper)
● Vaughn Dalzell (@VmoneySports)
● Trysta Krick (@Trista_Krick)