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Bills vs. Colts prediction: Odds, expert picks, QB matchup, injury report, betting trends and stats

The best term to describe the Indianapolis Colts’ (4-5) season to date might just be “wandering”. They have done little to excite their fan base and while they have yet to lose three in a row this season, they also have not won three in a row. They put the former streak to the test Sunday against the Buffalo Bills.

Week 1 of the Joe Flacco experience last Sunday produced little offense for the Colts in a 21-13 loss to the Vikings. It marked the 4th straight game Indianapolis failed to score more than 20 points. Their defense forced 3 turnovers against Minnesota but the offense could not convert those into enough points to defeat Sam Darnold and co.

While the Colts are struggling, the Buffalo Bills (7-2) are flourishing. Winners of 4 straight, the Bills have scored at least 30 points in 3 straight. Josh Allen (+300) is playing at an MVP level and the Buffalo defense has pieced it together despite a handful of significant injuries to build a commanding 4-game lead in the AFC East.

The Bills and Colts meet Sunday afternoon in Indianapolis.

Lets dive into the matchup and find a couple sweats.

NBC Sports has all the latest info and analysis you need, including how to tune in for kickoff, odds from DraftKings, player news and updates, and of course our predictions and best bets for the game from our staff of experts.

Listen to the Bet the Edge podcast as hosts Jay Croucher and Drew Dinsick provide listeners with sharp actionable insight, market analysis and statistical data to help bettors gain more information before placing their wagers.

Game Details and How to watch Bills @ Colts

  • Date: Sunday, November 10, 2024
  • Time: 1PM EST
  • Site: Lucas Oil Stadium
  • City: Indianapolis, IN
  • TV/Streaming: CBS

Want to check out the other games on the NFL schedule this week? We’ve got you covered right here on NBC Sports with all the matchup, venue, game-time and TV/streaming info so you won’t miss any of the action!

Game odds for Bills @ Colts

The latest odds as of Wednesday courtesy of DraftKings:

  • Moneyline: Buffalo Bills (-192), Indianapolis Colts (+160)
  • Spread: Bills -3.5
  • Total: 47

This line just moved 0.5 points towards the Colts. The Total dropped 0.5 points as well from its opening number of 47.5.

NBC Sports Bet Best Bets

Expert picks & predictions for Bills @ Colts

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NFL calendar based on data points like past performance, player matchups, betting trends, and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Sunday’s game between Buffalo and Indianapolis:

· Moneyline: NBC Sports is recommending a play on the Bills on the Moneyline
· Spread: NBC Sports is leaning towards a play on the Bills to cover the 3.5-point spread.
· Total: NBC Sports is leaning towards a play on the Total OVER 47.

Buffalo Bills and Indianapolis Colts Betting Trends and Stats

· The Bills have covered the spread in their last three games as road favorites.
· The UNDER has hit in the Colts’ last four games.
· The Colts have won four of their last five games against AFC East teams
· Buffalo is 5-4 ATS and 5-4 to the OVER this season.
· Indianapolis is 7-2 ATS and 3-6 to the OVER this season.

Quarterback matchup for Bills @ Colts

  • Buffalo: Josh Allen – the veteran has multiple TD passes in 4 straight games (all Bills’ wins). Has thrown 17 TD passes and just 2 INTs (although both interceptions have come in the last 2 weeks.
  • Indianapolis: Joe Flacco – the elevation to starting signal-caller did not have the desired effect on the Colts. The veteran completed 16 of 27 passes for a mere 179 yards against the Vikings. Flacco was also sacked 3 times this past weekend.

Bills and Colts injury update

· Buffalo WR Amari Cooper (wrist) is questionable for Sunday’s game.
· Buffalo WR Keon Coleman (wrist) is questionable for Sunday’s game.
· Buffalo DE Dawuane Smoot (wrist) was placed on IT on Tuesday and is OUT for Sunday’s game.
· Buffalo CB Christian Baford (wrist) is questionable for Sunday’s game.
· Buffalo FB Reggie Gilliam (undisclosed) is questionable for Sunday’s game.
· Indianapolis OT Bernard Raimann (concussion) is questionable for Sunday’s game.
· Indianapolis C Ryan Kelly (knee) was placed on IR on Tuesday and is OUT for Sunday’s game.

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