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Orioles at Blue Jays prediction: Odds, expert picks, starting pitchers, betting trends, and stats for Mar. 27

The Baltimore Orioles and Toronto Blue Jays open the 2025 regular season Thursday north of the border in Toronto.

Zach Eflin is slated to take the mound for Baltimore against José Berríos for Toronto.

Lets dive into the matchup and find a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch tipoff, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Follow Rotoworld Player News for the latest fantasy and betting player news and analysis all season long.

Game details & how to watch Orioles at Blue Jays

  • Date: Thursday, March 27, 2025
  • Time: 3:07PM EST
  • Site: Rogers Centre
  • City: Toronto, Ontario
  • Network/Streaming: MASN, SportsNet Now

Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.

Odds for the Orioles at the Blue Jays

The latest odds as of Wednesday:

  • Moneyline: Baltimore Orioles (-115), Toronto Blue Jays (-105)
  • Spread: Orioles -1.5 (+145), Blue Jays +1.5 (-175)
  • Total: 8.5 runs

Probable starting pitchers for Orioles at Blue Jays

  • Thursday’s pitching matchup (March 27): Zach Eflin vs. José Berríos
    • Orioles: Zach Eflin
      Spring Training - 4GP, 11.2 IP, 0-1, 5.40 ERA, 9 Ks
    • Blue Jays: José Berríos
      Spring Training - 5GP, 20.2 IP, 2-0, 2.18 ERA, 18 Ks

Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!

Top betting trends & insights to know ahead of Orioles at Blue Jays

  • Certain to be in the news all summer, Vladimir Guerrero hit .298 in Spring Training for Toronto
  • Bo Bichette led the Jays with a .373 average this Spring
  • Ryan Mountcastle led the Orioles with 5 HRs this Spring
  • Jackson Holliday went 16-48 (.333) this Spring for the O’s

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!

Expert picks & predictions for Thursday’s game between the Orioles and the Blue Jays

NBC Sports Bet Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Thursday’s game between the Orioles and the Blue Jays:

  • Moneyline: NBC Sports Bet is recommending a play on Toronto on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Toronto Blue Jays +1.5.
  • Total: NBC Sports Bet is recommending a play on the under on the Game Total of 8.5.

Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC

Follow our experts on socials to keep up with all the latest content from the staff:

  • Jay Croucher (@croucherJD)
  • Drew Dinsick (@whale_capper)
  • Vaughn Dalzell (@VmoneySports)
  • Brad Thomas (@MrBradThomas)