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Florida State at No. 25 Louisville Prediction: Odds, Expert Picks, Betting Trends and Stats

No. 25 Louisville (20-6, 13-2) looks to stay within range of the Duke Blue Devils and the top of the ACC Saturday when they take the court at the KFC YUM! Center against Florida State (16-10, 7-8).

The Cardinals have won four in a row to pull within 1.5 games of the Blue Devils. Last Sunday they won in South Bend, defeating the Fighting Irish 75-60.

Florida State has won three of their last four including a win Wednesday night at home against Miami, 74-66.

Louisville is 10-3 at home and FSU is 2-6 on the road this season.

Lets dive into the matchup and offer some information and possibly a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch the opening tip, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Game details & how to watch Seminoles at Cardinals

  • Date: Saturday, February 22, 2025
  • Time: 12:00PM EST
  • Site: KFC Yum! Center
  • City: Louisville, KY
  • Network/Streaming: The CW Network

Never miss a second of the action and stay up to date with all the latest scores and player news. Check out our day-by-day NCAA Basketball Schedule Page that includes live game updates.

Game odds for Florida State at Louisville

*odds courtesy of BetMGM

  • Odds: Florida State Seminoles (+675), Louisville Cardinals (-1100)
  • Spread: Cardinals -13.5
  • Total: 152.5 points

Bet the Edge is your source for all things sports betting. Get all of Jay Croucher and Drew Dinsick’s insight weekdays at 6AM ET right here or wherever you get your favorite podcasts.

Expert picks & predictions for Florida State at Louisville

NBC Sports Bet Best Bet

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Our model calculates projections around each moneyline, spread and over/under bet for every game on the NCAA calendar based on data points like past performance, player matchups, injuries, and the schedule.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for today’s Seminoles & Cardinals game:

  • Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Florida State at +13.5.
  • Total: NBC Sports Bet is recommending a play on the under on the Game Total of 152.5.

Seminoles vs Cardinals: Top betting trends and recent stats

  • Louisville has won 7 straight home games
  • 9 of Louisville’s last 10 games against Florida State have gone over the Total
  • FSU is 7-3 against the spread in its last 10 games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our NCAA Basketball Top Trends Tool on NBCSports.com!

Follow our experts on socials to keep up with all the latest content from the staff:
· Jay Croucher (@croucherJD)
· Drew Dinsick (@whale_capper)
· Vaughn Dalzell (@VmoneySports)
· Brad Thomas (@MrBradThomas)

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