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Creighton vs. Auburn Prediction: Odds, Expert Picks, Betting Trends, and Stats for 2025 March Madness Round 2

The Auburn Tigers (29-5), the No. 1 seed in the South Region, will face the No. 9 seed Creighton Bluejays (25-10) in the second round of the NCAA Tournament on Saturday at Rupp Arena in Lexington, Kentucky.

Auburn advanced to Round 2 with an 83-63 win over the Hornets of Alabama State. Miles Kelly scored 23 points to lead the Tigers. He was 7-15 from three-point range. Johni Broome had 14 points and 11 boards. The Tigers’ 83 points was on par with their season average of 83.8 points per game.

Creighton knocked out the Louisville Cardinals, 89-75, Thursday in the Opening Round. Jamiya Neal was dominant in the game scoring 29 points and pulling down 12 rebounds. The Blue jays shot 57.1% from the field (32-56) and 45.8% from three (11-24) in the game.

The winner of this game advances to the Sweet 16 and a game against the winner of the Texas A&M vs. Michigan game.

Lets dive into the matchup and offer some information and possibly a sweat or two.

We’ve got all the info and analysis you need to know ahead of the game, including the latest info on the how to catch the opening tip, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.

Game details & how to watch Creighton vs. Auburn

  • Date: Saturday, March 22, 2025
  • Time: 7:10PM EST
  • Site: Rupp Arena
  • City: Lexington, KY
  • Network/Streaming: TBS/truTV

Never miss a second of the action and stay up to date with all the latest scores and player news. Check out our day-by-day NCAA Basketball Schedule Page that includes live game updates.

Game odds for Creighton vs. Auburn

The latest odds as of Friday courtesy of BetMGM:

  • Odds: Creighton Bluejays (+350), Auburn Tigers (-475)
  • Spread: Auburn Tigers -9.5
  • Total: 150.5 points

Expert picks & predictions for Creighton vs. Auburn

NBC Sports Bet Best Bet

Our model calculates projections around each moneyline, spread and over/under bet for every game on the NCAA calendar based on data points like past performance, player matchups, injuries, and the schedule.

Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.

Here are the best bets our model is projecting for Saturday’s Bluejays & Tigers game:

  • Moneyline: NBC Sports Bet is staying away from a play on the Moneyline.
  • Spread: NBC Sports Bet is leaning towards a play ATS on the Creighton Bluejays +9.5.
  • Total: NBC Sports Bet is recommending a play on the Game Total OVER 150.5.

Creighton vs. Auburn: Top betting trends and recent stats

  • Auburn has failed to cover the spread in their last 5 and in 7 of their last 9 games
  • Auburn Game Totals have cashed to the UNDER in three straight games
  • Creighton covered and the OVER cashed in their game against Louisville
  • Creighton is 5-5 against the spread in their last 10 games

If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our NCAA Basketball Top Trends Tool on NBCSports.com!

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Follow our experts on socials to keep up with all the latest content from the staff:

· Jay Croucher (@croucherJD)

· Drew Dinsick (@whale_capper)

· Vaughn Dalzell (@VmoneySports)

· Brad Thomas (@MrBradThomas)

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