Patriots QB Tom Brady's dominance over the Bills summed up in one stat

Few players in NFL history have dominated one team as much as New England Patriots quarterback Tom Brady has dominated the Buffalo Bills.

Brady has a 30-3 record in his career against the Bills, giving him the most victories by a quarterback versus a single opponent. Here's the top five:

1. Tom Brady, 30 wins vs. Bills
2. Tom Brady, 28 wins vs. Jets
3. Brett Favre, 26 wins  vs. Lions
4. Tom Brady, 23 wins vs. Dolphins
5. Brett Favre, 23 wins vs. Bears; Ben Roethlisberger, 23 wins vs. Bengals

Brady and the Patriots soon will travel to Buffalo for Sunday's Week 4 matchup at New Era Field, where first place in the AFC East will be on the line. The Patriots and Bills enter this matchup with identical 3-0 records, and Brady is expecting a great test from Buffalo's defense.

"They’ve been ranked up there for a while now, and I think they’re good at all levels, so that’s the challenging part," Brady told reporters Wednesday. "They have a good front, very good at linebacker, very good in the secondary, play the pass well, tough, physical, stout defense, well-coached, fundamentally sound. They play well at home; it’s a great environment. So, it’s pretty tough, it’s pretty tough. It’s a great challenge. They’re 3-0, they’re off to a great start, they’ve got a very good football team and it’s going to be really a great environment for football. They’re going to challenge us. This will be the toughest game we’ve faced, and we’re going to have to play a great game."

Brady has enjoyed remarkable success in Buffalo, and his 15 wins at New Era Field since 2001 are the most by any quarterback, even among those who've played for the Bills. The Patriots also have won five straight games against the Bills, and oddsmakers are predicting another victory.

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Not only will the Patriots have to battle a formidable Bills defense in Week 4, they also have to deal with one of the rowdiest fanbases in the league. This matchup will be one of the most anticipated Bills home games in recent memory given the fact both teams are undefeated.

"When you go on the road in the NFL, you’ve got to get used to that because that’s a lot of what that’s about," Brady said Wednesday. "You go in there with however many guys – 46 active, five or six other guys, your coaches, a few fans in the crowd – but I think it’s always gratifying when you go in there and then by the end of the game, you look up and there’s only Patriots fans left.

"I always think that’s pretty cool. So, to go on the road in the NFL is tough, and certainly early in the game, after their pregame tailgate when they’re a little fired up. So, they’re pretty into it, they’re pretty loud and we’ve got to go out and we’ve got to execute early. I think starting fast, which we’ve actually done a good job with this year, that’s really important this week."

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